Risiko Keparahan pada Pasien Covid-19 dengan Komorbiditas Penyakit Ginjal Kronis: Meta Analisis

Authors

  • Tri Yuniarti STIKES Mamba'ul 'Ulum Surakarta
  • Anita Dewi Lieskusumastuti STIKES Mamba’ul ‘Ulum Surakarta
  • Joko Tri Atmojo STIKES Mamba’ul ‘Ulum Surakarta
  • Aris Widiyanto STIKES Mamba’ul ‘Ulum Surakarta
  • HAkim Anasulfalah STIKES Mamba’ul ‘Ulum Surakarta

DOI:

https://doi.org/10.32583/pskm.v13i2.957

Keywords:

chronic kidney disease, COVID-19, SARS-CoV-2, severity

Abstract

COVID-19 adalah penyakit yang disebabkan oleh severe acute respiratory coronavirus 2 (SARS-CoV-2). Hipertensi, diabetes melitus, penyakit kardiovaskular, penyakit paru obstruktif kronik, penyakit ginjal kronis, penyakit serebrovasular, dan kanker merupakan beberapa komorbid dari COVID-19 yang terbanyak pada saat ini. Penelitian ini bertujuan untuk mengestimasi besarnya risiko tingkat keparahan pada pasien COVID-19 dengan komorbiditas penyakit ginjal kronis, dengan meta analisis. Penelitian ini merupakan systematic review dan meta analisis dengan PICO sebagai berikut, population: pasien COVID-19. Intervention: komorbiditas penyakit ginjal kronis. Comparison: tanpa komorbiditas penyakit ginjal kronis. Outcome: keparahan. Artikel yang digunakan dalam penelitian ini diperoleh dari tiga database yaitu Google Scholar, Pubmed, dan Science Direct. Kata kunci untuk mencari artikel “Chronic Renal Disease” OR “Chronic Kidney Disease” AND COVID-19 OR SARS-CoV-2 AND Severity. Artikel yang digunaan dari tahun 2020 – 2022. Pemilihan artikel dilakukan dengan menggunakan PRISMA flow diagram. Artikel dianalisis menggunakan aplikasi Review Manager 5.3. Sebanyak 8 studi kohor melibatkan 234,124 pasien COVID-19 dari Amerika, Eropa, dan Asia terpilih untuk dilakukan systematic review dan meta analisis. Data yang dikumpulkan menunjukkan pasien COVID-19 dengan komorbiditas penyakit ginjal kronis memiliki risiko tingkat keparahan sebanyak 2.43 kali dibandingkan dengan pasien COVID-19 tanpa komorbiditas penyakit ginjal kronis (aOR= 2.43; CI 95%= 1.56 hingga 3.52; p< 0.001). Penyakit ginjal kronis meningkatkan risiko keparahan pada pasien COVID-19.

References

Almazeedi S, Al-Youha S, Jamal MH, Al-Haddad M, Al-Muhaini A, Al-Ghimlas, Al-Sabbah S (2020). Characteristics, risk factors and outcomes among Kuwait's first consecutive 1096 patients diagnosed with COVID-19. EClinicalMedicine. 24 (100448) 1-9. doi: 10.1016/j.eclinm.¬2020.100448.

Benedetti C, Waldman M, Zaza G, Riella LV, Cravedi P (2020). COVID-19 and The kidneys: an update. Front Med (Lausanne). https://doi.org/10.3389/fmed.2020.00423

Bourgonje AR, Abdulle AE, Timens W, Hillebrands J, Navis GJ, Gordijn SJ, Bolling MC (2020). Angiotensin-converting enzyme-2 (ACE2), SARS-CoV-2 and pathophysiology of coronavirus disease 2019 (COVID-19). J. Pathol. 251(3):228-248. doi: 10.1002/path.5471.

CASP (2018). Critical appraisal skills program cohort study checklist. Retrieved from https://casp-uk.net/¬wpcontent/uploads/2018/01/CASP-Cohort-Study-Checklist_2018.pdf.

Chen Y, Guo Y, Pan Y, Zhao ZJ (2020). Structure analysis of the receptor binding of 2019-nCoV. Biochem Biophys Res Commun. 525(1): 135-140. doi: 10.1016/j.bbrc.2020.02.071.

Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. (2020). Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. ;97(5):829–38. https:// doi. org/10. 1016/j. knit. 2020. 03. 005.

Cuker A, Flora P (2021). COVID-19: Hypercoagulability. Retrieved from https://www.uptodate.com/contents/covid-19-hypercoagulability.

Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J, Wang H et al. (2004). Organ distribution of severe acute respire¬tory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for patho¬genesis and virus transmission pathways. J Pathol. 203 (2): 622-630. doi: 10.1002/-path.1560.

Gabarre P, Dumas G, Dupont T, Darmon M, Azoulay E, Zafrani L. Acute kidney injury in critically ill patients with COVID-19 (2020). Intensive Care Med.46(7):1339–48. https:// doi. org/ 10. 1007/s00134- 020- 06153-9.

Gansevoort RT, Correa-Rotter R, Hemmelgarn BR, Jafar TH, Heerspink HJL, Mann JF, Matsushita K et al. (2013). Chronic kidney disease and cardiovascular risk: epidemio-logy, mechanisms, and prevention. Lancet. 382 (9889): 339-352. doi: 10.1016/S0140-6736(13)-60595-4.

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, Liu L et al. (2020). Clinical characteristics of coronavirus disease 2019 in china. New Eng J Med. 382 (18): 1708-1720. doi: 10.1056/NEJM¬oa2002032.

Li X, Geng M, Peng Y, Meng L, Lu S (2020). Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 10 (2): 102-108. doi: 10.1016/j.jpha.2020.03.001.

Matsushita K, Velde MVD, Astor BC, Woodward M, Levey AS, Jong PED, Coresh J et al. (2010). Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality: a collaborative meta-analysis of general popular-tion cohorts. Lancet. 375(9731): 2073-2081. doi: 10.1016/S0140 6736(10)¬60674-5.

NIH (2017). Chronic kidney disease (CKD). National institutes of health. Retriev¬ed from https://www.niddk¬.nih.gov¬/health-information/kidney-disease¬/chronic-kidneydisease-ckd/¬what-is-chronic-kidney-disease.

O’Callaghan CA, Shine B, Lasserson DS (2011). Chronic kidney disease: a large-scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting. BMJ Open. 1 (2): 1-10. doi: 10.1136/bmj¬open-2011-000308.

Rocha S, Valente MJ, Coimbra S, Catarino C, Rocha-Pereira P, Oliveira JG, Madureira J et al. (2021). Interleukin 6 (rs1800795) and pentraxin 3 (rs2305619) polymorphisms-associa¬tion with inflammation and all-cause mortality in end-stage renal disease patients on dialysis. Sci Rep. 11: 14768. doi: 10.1038/s41598-021-940¬75-x.

Ruan Q, Yang K, Wang W, Jiang L, Song J (2020). Clinical predictors of mortality due to COVID-19 based on an analysis of data from 150 patients from Wuhan, China. Intensive Care Med. 46: 846-848. DOI: 10.1007-/s00134-020-05991-x.

WHO (2021). WHO coronavirus (COVID-19) Dashboard. World Health Organi- zation. Retrieved from https://covid¬19¬.who.int/.

Widiyanto, A., Peristiowati, Y., Ellina, A. D., Duarsa, A. B. S., Fajria, A. S., & Atmojo, J. T. (2022). Peningkatan Imunitas Tubuh melalui Konsumsi Vitamin dalam Menghadapi Covid-19: Systematic Review. Jurnal Keperawatan, 14(S1), 95-104.

Willim HA, Hardigaloeh AT, Supit AI, Handriyani (2020). Koagulopati pada Coronavirus Disease-2019 (COVID-19): Tinjauan Pustaka. Intisari Sains Medis. 11 (3): 749-756. doi: 10.155¬62/ism.v11i3.766.

Zou X, Chen K, Zou J, Han P, Hao J, Han Z (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 12: 1-8. doi: 10.13.

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Published

2023-03-25

How to Cite

Yuniarti, T., Lieskusumastuti, A. D., Atmojo, J. T., Widiyanto, A., & Anasulfalah, H. (2023). Risiko Keparahan pada Pasien Covid-19 dengan Komorbiditas Penyakit Ginjal Kronis: Meta Analisis. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 13(2), 645–656. https://doi.org/10.32583/pskm.v13i2.957

Issue

Vol. 13 No. 2 (2023): Jurnal Ilmiah Permas: jurnal Ilmiah STIKES Kendal: April 2023

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article

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