Meta-Analisis Efektivitas Madu dalam Penyembuhan Luka

Authors

  • Sri Iswahyuni Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Ahmad Syauqi Mubarok Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Rejo Rejo Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Aris Widiyanto Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Joko Tri Atmojo Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta

DOI:

https://doi.org/10.32583/pskm.v14i1.1833

Keywords:

luka, madu, penderita

Abstract

Luka merupakan serangan terhadap fungsi pelindung kulit; hilangnya kontinuitas epitel, dengan atau tanpa hilangnya jaringan ikat di bawahnya (misalnya otot, tulang, saraf). Madu dapat mempertahankan kelembapan, merangsang pertumbuhan jaringan, angiogenesis, granulasi, kontraksi luka, merangsang sintesis kolagen, memperlancar proses debridemen dan mempercepat epitelisasi luka. Penelitian ini bertujuan untuk mengetahui efektivitas madu dalam penyembuhan luka. Penelitian ini merupakan penelitian sys­te­ma­tic review dan meta-analysis denagn menggunakan diagram PRISMA. Pencarian artikel dilakukan berdasarkan kriteria kela­yakan Model PICO. P= Penderita luka; I= Menggunakan madu; C= Tidak menggunakan madu; O= Penyembuhan luka.  Artikel yang digunakan berasal dari  PubMed dan Google Scho­lar. Dengan kata kun­ci antara lain “Wound” AND “honey” AND “randomized controlled trial”.  Tahun 2018 – 2021 Artikel dianalisis menggunakan digram PRISMA dan aplikasi Review Manager 5.3. 5 artikel dengan de­sain studi randomized controlled trial yang akan digu­nakan sebagai sumber meta-analisis efektivitas madu dalam penyembuhan luka. Menunjukan bahwa menggunakan madu meningkatkan kemungkinan penyembuhan luka. Penderita luka yang mengguankan madu meningkatkan penyembuhan luka sebesar 0.05 kali dibandingkan dengan penderita luka yang tidak menggunakan madu. (SMD= 0.05; CI 95%= -0.66 hingga 0.77; p=0.0001), dan signifikan secara statistik. Forest plot tersebut juga menunjukkan heterogenitas estimasi efek antar studi yang tinggi (I2 = 93%). Funnel plot menunjukkan terdapat bias publikasi yang cenderung melebih-lebihkan efek yang sesungguhnya (overestimate). Meta-analisis dari 5 studi randomized controlled trial menyimpulkan bahwa menggunakan madu meningkatkan kemungkinan penyembuhan luka.

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Published

2023-11-18

How to Cite

Iswahyuni, S., Mubarok, A. S. ., Rejo, R., Widiyanto, A., & Atmojo, J. T. (2023). Meta-Analisis Efektivitas Madu dalam Penyembuhan Luka. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 14(1), 467–474. https://doi.org/10.32583/pskm.v14i1.1833

Issue

Vol. 14 No. 1 (2024): Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal: Januari 2024

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article

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