Meta-Analisis Efektivitas Madu dalam Penyembuhan Luka

Authors

  • Sri Iswahyuni Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Ahmad Syauqi Mubarok Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Rejo Rejo Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Aris Widiyanto Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta
  • Joko Tri Atmojo Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta

DOI:

https://doi.org/10.32583/pskm.v14i1.1833

Keywords:

luka, madu, penderita

Abstract

Luka merupakan serangan terhadap fungsi pelindung kulit; hilangnya kontinuitas epitel, dengan atau tanpa hilangnya jaringan ikat di bawahnya (misalnya otot, tulang, saraf). Madu dapat mempertahankan kelembapan, merangsang pertumbuhan jaringan, angiogenesis, granulasi, kontraksi luka, merangsang sintesis kolagen, memperlancar proses debridemen dan mempercepat epitelisasi luka. Penelitian ini bertujuan untuk mengetahui efektivitas madu dalam penyembuhan luka. Penelitian ini merupakan penelitian sys­te­ma­tic review dan meta-analysis denagn menggunakan diagram PRISMA. Pencarian artikel dilakukan berdasarkan kriteria kela­yakan Model PICO. P= Penderita luka; I= Menggunakan madu; C= Tidak menggunakan madu; O= Penyembuhan luka.  Artikel yang digunakan berasal dari  PubMed dan Google Scho­lar. Dengan kata kun­ci antara lain “Wound” AND “honey” AND “randomized controlled trial”.  Tahun 2018 – 2021 Artikel dianalisis menggunakan digram PRISMA dan aplikasi Review Manager 5.3. 5 artikel dengan de­sain studi randomized controlled trial yang akan digu­nakan sebagai sumber meta-analisis efektivitas madu dalam penyembuhan luka. Menunjukan bahwa menggunakan madu meningkatkan kemungkinan penyembuhan luka. Penderita luka yang mengguankan madu meningkatkan penyembuhan luka sebesar 0.05 kali dibandingkan dengan penderita luka yang tidak menggunakan madu. (SMD= 0.05; CI 95%= -0.66 hingga 0.77; p=0.0001), dan signifikan secara statistik. Forest plot tersebut juga menunjukkan heterogenitas estimasi efek antar studi yang tinggi (I2 = 93%). Funnel plot menunjukkan terdapat bias publikasi yang cenderung melebih-lebihkan efek yang sesungguhnya (overestimate). Meta-analisis dari 5 studi randomized controlled trial menyimpulkan bahwa menggunakan madu meningkatkan kemungkinan penyembuhan luka.

References

Arentz, S., Hunter, J., Khamba, B., Mravunac, M., Lee, Z., Alexander, K., Lauche, R., Goldenberg, J., & Myers, S. P. (2021). Honeybee products for the treatment and recovery from viral respiratory infections including SARS-COV-2: A rapid systematic review. Integrative Medicine Research, 10. https://doi.org/10.1016/j.imr.2021.100779

Chotchoung, S., Krairit, O., Tragulpiankit, P., & Prathanturarug, S. (2020). The efficacy of honey and a Thai Herbal Oil preparation in the treatment of pressure ulcers based on Thai traditional medicine wound diagnosis versus standard practice: An open-label randomized controlled trial. Contemporary Clinical Trials Communications, 17, 100538. https://doi.org/10.1016/j.conctc.2020.100538

Faradisi, F., & Aktifah, N. (2022). The Effectiveness of Honey Dressing on Wound Healing Time In Rabits (Wistar Line). 646–649.

Hossain, M. L., Lim, L. Y., Hammer, K., Hettiarachchi, D., & Locher, C. (2021). Honey-based medicinal formulations: A critical review. Applied Sciences (Switzerland), 11(11), 1–18. https://doi.org/10.3390/app11115159

Ibrahim, S. S., Abou-Bakr, A., Ghalwash, D. M., & Hussein, R. R. (2023). Effectiveness of thyme honey in the management of xerostomia in geriatric patients with end-stage renal disease: a randomized controlled clinical trial with a biochemical assessment. European Journal of Medical Research, 28(1), 406. https://doi.org/10.1186/s40001-023-01351-9

Indarto, I., Widiyanto, A., & Atmojo, J. T. (2023). Efektivitas Metformin dalam Penurunan Kadar Glukosa pada Pasien Diabetes Mellitus Tipe-2: Meta-Analisis. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 13(2), 621-630.

Karimi, Z., Behnammoghadam, M., Rafiei, H., Abdi, N., Zoladl, M., Talebianpoor, M. S., Arya, A., & Khastavaneh, M. (2019). Impact of olive oil and honey on healing of diabetic foot: A randomized controlled trial. Clinical, Cosmetic and Investigational Dermatology, 12, 347–354. https://doi.org/10.2147/CCID.S198577

Kassem, L. M., El-Deen, A. G., Zaki, A. H., & El-Dek, S. I. (2023). Electrospun manuka honey@PVP nanofibers enclosing chitosan-titanate for highly effective wound healing. Cellulose, 30(10), 6487–6505. https://doi.org/10.1007/s10570-023-05267-9

Kesehatan Masyarakat UNS. (2023). Penilaian Kualitas Studi Primer untuk. 36, 3–4.

Konuk Sener, D., Aydin, M., Cangur, S., & Guven, E. (2019). The Effect of Oral Care with Chlorhexidine, Vitamin E and Honey on Mucositis in Pediatric Intensive Care Patients: A Randomized Controlled Trial. Journal of Pediatric Nursing, 45, e95–e101. https://doi.org/10.1016/j.pedn.2019.02.001

Koujalagi, R. S., Uppin, V. M., Shah, S., & Sharma, D. (2020). One year randomized controlled trial to compare the effectiveness of honey dressing versus povidone iodine dressing for diabetic foot ulcer at Dr. Prabhakar Kore Hospital and MRC, Belagavi. International Surgery Journal, 7(2), 506. https://doi.org/10.18203/2349-2902.isj20200306

Nikhat, S., & Fazil, M. (2022). History, phytochemistry, experimental pharmacology and clinical uses of honey: A comprehensive review with special reference to Unani medicine. Journal of Ethnopharmacology, 282(September 2021), 114614. https://doi.org/10.1016/j.jep.2021.114614

Nugroho, Y. H., Riyanto, P., Indar, R., Budiastuti, A., Adriani, D., & M, M. (2022). Effectiveness of Honey Dressing in Wound Healing: Systematic Review and Metaanalysis. Journal of Medical - Clinical Research & Reviews, 6(2), 1–7. https://doi.org/10.33425/2639-944x.1260

Poovelikunnel, T. T., Gethin, G., Solanki, D., McFadden, E., Codd, M., & Humphreys, H. (2018). Randomized controlled trial of honey versus mupirocin to decolonize patients with nasal colonization of meticillin-resistant Staphylococcus aureus. Journal of Hospital Infection, 98(2), 141–148. https://doi.org/10.1016/j.jhin.2017.10.016

Sukarno, A., Hidayah, N., & Musdalifah, M. (2019). Effectivity of Indonesian Honey on Diabetic Foot Ulcers Healing Process: Observational Case Study. International Journal of Nursing and Health Services (IJNHS), 2(2), 20–28. https://doi.org/10.35654/ijnhs.v2i2.88

Vas, P., Rayman, G., Dhatariya, K., Driver, V., Hartemann, A., Londahl, M., Piaggesi, A., Apelqvist, J., Attinger, C., & Game, F. (2020). Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review. Diabetes/Metabolism Research and Reviews, 36(S1), 1–23. https://doi.org/10.1002/dmrr.3284

Wang, C., Guo, M., Zhang, N., & Wang, G. (2019). Effectiveness of honey dressing in the treatment of diabetic foot ulcers: A systematic review and meta-analysis. Complementary Therapies in Clinical Practice, 34(September 2018), 123–131. https://doi.org/10.1016/j.ctcp.2018.09.004

Weigelt, M. A., McNamara, S. A., Sanchez, D., Hirt, P. A., & Kirsner, R. S. (2021). Evidence-based review of antibiofilm agents for wound care. Advances in Wound Care, 10(1), 13–23. https://doi.org/10.1089/wound.2020.1193

Yu, Y. T., Deng, J. L., Jin, X. R., Zhang, Z. Z., Zhang, X. H., & Zhou, X. (2020). Effects of 9 oral care solutions on the prevention of oral mucositis: a network meta-analysis of randomized controlled trials. Medicine (United States), 99(16), E19661. https://doi.org/10.1097/MD.0000000000019661

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Published

2023-11-18

How to Cite

Iswahyuni, S., Mubarok, A. S. ., Rejo, R., Widiyanto, A., & Atmojo, J. T. (2023). Meta-Analisis Efektivitas Madu dalam Penyembuhan Luka. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 14(1), 467–474. https://doi.org/10.32583/pskm.v14i1.1833

Issue

Vol. 14 No. 1 (2024): Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal: Januari 2024

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article

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