Ekstrak Moringa Oleifera Mempercepat Proses Penyembuhan Luka: Systematic Review
DOI:
https://doi.org/10.32583/far.v12i2.1109Keywords:
moringa oleifera, penyembuhan luka, sistem imunAbstract
Kulit merupakan organ terluar dan terbesar pada tubuh yang berfungsi sebagai barrier dari lingkungan eksternal. Luka yang terjadi pada jaringan kulit dapat menjadi lesi atau penyakit. Mekanisme penyembuhan luka dilakukan untuk melindungi tubuh. Artikel ini bertujuan untuk mengertahui peran ekstrak Moringa Oleifera pada system imun dalam proses penyembuhan luka. Metode yang digunakan adalah sistematik review. Penelusuran artikel dilakukan pada 5 database yaitu : PubMed, Science Direct, ProQuest, Springer Link dan Google Scholar. Data yang diperoleh dari seleksi literatur sejumlah tujuh dari 198 artikel. Hasil dari review ini menunjukkan bahwa ekstrak Moringa oleifera mempercepat penyembuhan luka. Moringa oleifera juga efektif pada beragam mekanisme seberti antimikroba, antioksidan, proliferasi, penutupan luka lebih cepat. Pemanfataan ekstrak Moringa oleifera dapat berasal dari ekstrak biji ataupun daun dan dimanfaatkan baik pada penyembuhan luka pada kondisi normal, diabetes, dan infeksi patogen.
References
Al-Ghanayem, A. A., Alhussaini, M. S., Asad, M., & Joseph, B. (2022a). Moringa oleifera Leaf Extract Promotes Healing of Infected Wounds in Diabetic Rats: Evidence of Antimicrobial, Antioxidant and Proliferative Properties. Pharmaceuticals, 15(5). https://doi.org/10.3390/ph15050528
Al-Ghanayem, A. A., Alhussaini, M. S., Asad, M., & Joseph, B. (2022b). Effect of Moringa oleifera Leaf Extract on Excision Wound Infections in Rats: Antioxidant, Antimicrobial, and Gene Expression Analysis. Molecules, 27(14). https://doi.org/10.3390/molecules27144481
Ali, A., Garg, P., Goyal, R., Kaur, G., Li, X., Negi, P., Valis, M., Kuca, K., & Kulshrestha, S. (2021). A novel herbal hydrogel formulation of moringa oleifera for wound healing. Plants, 10(1), 1–13. https://doi.org/10.3390/plants10010025
Arulselvan, P., Tan, W. S., Gothai, S., Muniandy, K., Fakurazi, S., Mohd Esa, N., Alarfaj, A. A., & Kumar, S. S. (2016). Anti-inflammatory potential of ethyl acetate fraction of moringa oleifera in downregulating the NF-κB signaling pathway in lipopolysaccharide-stimulated macrophages. Molecules, 21(11). https://doi.org/10.3390/molecules21111452
Azevedo, Í. M., Araújo-Filho, I., Teixeira, M. M. A., Moreira, M. D. F. de C., & Medeiros, A. C. (2018). Wound healing of diabetic rats treated with moringaoleifera extract. Acta Cirurgica Brasileira, 33(9), 799–805. https://doi.org/10.1590/s0102-865020180090000008
Broughton, G. I. I., Janis, J. E., & Attinger, C. E. (2006). The Basic Science of Wound Healing. Plastic and Reconstructive Surgery, 117(7S). https://journals.lww.com/plasreconsurg/Fulltext/2006/06001/The_Basic_Science_of_Wound_Healing.5.aspx
Cooper, C., Booth, A., Varley-Campbell, J., Britten, N., & Garside, R. (2018). Defining the process to literature searching in systematic reviews: A literature review of guidance and supporting studies. In BMC Medical Research Methodology (Vol. 18, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s12874-018-0545-3
Guo, B., Dong, R., Liang, Y., & Li, M. (2021). Haemostatic materials for wound healing applications. Nature Reviews Chemistry, 5(11), 773–791. https://doi.org/10.1038/s41570-021-00323-z
Islam, Z., Islam, S. M. R., Hossen, F., Mahtab-Ul-Islam, K., Hasan, M. R., & Karim, R. (2021). Moringa oleifera is a Prominent Source of Nutrients with Potential Health Benefits. In International Journal of Food Science (Vol. 2021). Hindawi Limited. https://doi.org/10.1155/2021/6627265.
Kementrian Kesehatan RI. (2019). Laporan Riskesdas 2018 Nasional. http://repository.bkpk.kemkes.go.id/3514/1/Laporan%20Riskesdas%202018%20Nasional.pdf
Liang, L., Wang, C., Li, S., Chu, X., & Sun, K. (2019). Nutritional compositions of Indian Moringa oleifera seed and antioxidant activity of its polypeptides. Food Science and Nutrition, 7(5), 1754–1760. https://doi.org/10.1002/fsn3.1015
Lopes, T. D. P., Souza, P. F. N., da Costa, H. P. S., Pereira, M. L., da Silva Neto, J. X., de Paula, P. C., Brilhante, R. S. N., Oliveira, J. T. A., Vasconcelos, I. M., & Sousa, D. O. B. (2020). Mo-CBP4, a purified chitin-binding protein from Moringa oleifera seeds, is a potent antidermatophytic protein: In vitro mechanisms of action, in vivo effect against infection, and clinical application as a hydrogel for skin infection. International Journal of Biological Macromolecules, 149, 432–442. https://doi.org/10.1016/j.ijbiomac.2020.01.257
Mohammad Shafie, N., Raja Shahriman Shah, R. N. I., Krishnan, P., Abdul Haleem, N., & Tan, T. Y. C. (2022). Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies. In Molecules (Vol. 27, Issue 17). MDPI. https://doi.org/10.3390/molecules27175541
Oktaviani, D. J., Widiyastuti, S., Maharani, D. A., Amalia, A. N., Ishak, A. M., & Zuhrotun, A. (2019). Review: Bahan Alami Penyembuh Luka. Farmasetika.Com (Online), 4(3), 44. https://doi.org/10.24198/farmasetika.v4i3.22939
Pazyar, N. , Yaghoobi, R. , Rafiee, E. , Mehrabian, A. , & & Feily, A. (2014). Skin Wound Healing and Phytomedicine: A Review. Skin Pharmacology and Physiology. Skin Pharmacology and Physiology, 303–310. https://doi.org/https://doi.org/10.1159/000357477
Piipponen, M., Li, D., & Landén, N. X. (2020). The immune functions of keratinocytes in skin wound healing. In International Journal of Molecular Sciences (Vol. 21, Issue 22, pp. 1–26). MDPI AG. https://doi.org/10.3390/ijms21228790
Shady, N. H., Mostafa, N. M., Fayez, S., Abdel-Rahman, I. M., Maher, S. A., Zayed, A., Saber, E. A., Khowdiary, M. M., Elrehany, M. A., Alzubaidi, M. A., Altemani, F. H., Shawky, A. M., & Abdelmohsen, U. R. (2022). Mechanistic Wound Healing and Antioxidant Potential of Moringa oleifera Seeds Extract Supported by Metabolic Profiling, In Silico Network Design, Molecular Docking, and In Vivo Studies. Antioxidants, 11(9). https://doi.org/10.3390/antiox11091743
Shedoeva, A., Leavesley, D., Upton, Z., & Fan, C. (2019). Wound healing and the use of medicinal plants. In Evidence-based Complementary and Alternative Medicine (Vol. 2019). Hindawi Limited. https://doi.org/10.1155/2019/2684108
Tofiq, S. A., Azeez, H. A., & Othman, H. H. (2021). Wound healing activities of Moringa oleifera leaves extract cultivated in Kurdistan region-Iraq. Jordan Journal of Biological Sciences, 14(4), 637–645. https://doi.org/10.54319/jjbs/140403
Ventura, A. C. S. S. B., de Paula, T., Gonçalves, J. P., Soley, B. da S., Cretella, A. B. M., Otuki, M. F., & Cabrini, D. A. (2021). The oil from Moringa oleifera seeds accelerates chronic skin wound healing. Phytomedicine Plus, 1(3). https://doi.org/10.1016/j.phyplu.2021.100099
Vitale, S., Colanero, S., Placidi, M., Di Emidio, G., Tatone, C., Amicarelli, F., & D’Alessandro, A. M. (2022). Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research. Molecules, 27(11). https://doi.org/10.3390/molecules27113566.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Nur Al Marwah Asrul, Andi Tenri Ola Rivai, Syisnawati Syisnawati, Ruris Haristiani
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
