Hubungan Demografi (Pendidikan, Pekerjaan) dan Faktor Determinan (Pola Makan, Genetik, Obat-Obatan, Psikososial) Pasien Endometriosis terhadap Keberhasilan Kehamilan Program Bayi Tabung

Authors

  • Ulfah Nuraini Karim Universitas Binawan
  • Handayani Handayani Universitas Binawan
  • Widanarti Setyaningsih Universitas Binawan

DOI:

https://doi.org/10.32583/keperawatan.v16i4.2026

Keywords:

demografi, endometriosis, faktor determinan, keberhasilan kehamilan program bayi tabung

Abstract

Endometriosis ditandai adanya endometrium di luar rongga rahim dan infiltrasi jaringan ektopik, menyebabkan peradangan, nyeri, dan infertilitas. Keadaan infertilitas yang berkaitan dengan endometriosis terutama pada stadium III dan IV sering kali memerlukan Assisted Reproductive Technologies (ART) untuk dapat mencapai kehamilan, salah satunya adalah Fertilisasi in Vitro (FIV) / bayi tabung. Penelitian ini bertujuan untuk Menganalisa Hubungan Demografi (Pendidikan, Pekerjaan) Dan Faktor Determinan (Pola Makan, Genetik, Obat-Obatan, Psikososial) Pasien Endometriosis Terhadap Keberhasilan Kehamilan Program Bayi Tabung. Desain penelitian yang digunakan adalah penelitian mix method. Metode pengambilan sampel dengan purposive sampling dengan kriteria inklusi pasien di Klinik Yasmin yang mengalami endometriosis dan sedang melakukan program FIV yang telah mencapai embrio transfer berjumlah sebanyak 51 orang. Metode pengumpulan data menggunakan The explanatory sequential design dengan instrumen Form FFQ, hasil analisa pemeriksaan USG dan wawancara mendalam. Proses analisis data menggunakan analisis univariat dan analisis bivariat dengan uji korelasi Chi square, analisa kualitatif dengan metode Coalllizi’s. Hasil penelitian menunjukkan hasil uji statistik diperoleh nilai p < 0.05, maka terdapat hubungan Demografi (Pendidikan, Pekerjaan) Dan Faktor Determinan (Pola Makan, Genetik, Obat-Obatan) Pasien Endometriosis Terhadap Keberhasilan Kehamilan Program Bayi Tabung. Hasil kualitatif ditemukan 3 tema utama yang terdiri dari domain psiko-emosional, domain psikososial dan domain suport keluarga. Hasil penelitian dapat menjadi rujukan bagi perawat dalam perawatan Assisted Reproductive Technologies (ART) atau program pelayanan infertilitas sehingga keberhasilan program bayi tabung dapat ditingkatkan.

References

Bell, R. J., Robinson, P. J., Skiba, M. A., Islam, R. M., Hemachandra, C., & Davis, S. R. (2023). The impact of endometriosis on work ability in young Australian women. Australian and New Zealand Journal of Obstetrics and Gynaecology, 63(4), 556–563. https://doi.org/10.1111/ajo.13683

Dhyani, I., Yukhi, K., Made, O., (2020). Hubungan Antara Faktor-Faktor Penyebab Infertilitas Terhadap Tingkat Keberhasilan IVF-ICSI Di RSIA Puri Bunda Denpasar Pada Tahun 2017. Jurnal Medika Udayana (JMU), Vol 9 No.5, 1-7. DOI: https://doi.org/10.33992/jik.v10i1.1557

Elbasueny, B., Geerts, M., Yang, E. C., Allaire, C., Yong, P. J., & Bedaiwy, M. A. (2023). Medical treatments of endometriosis: A review. In Reproductive and Developmental Medicine (Vol. 7, Issue 3, pp. 166–179). Lippincott Williams and Wilkins. https://doi.org/10.1097/RD9.0000000000000053

Filby, C. E., Rombauts, L., Montgomery, G. W., Giudice, L. C., & Gargett, C. E. (2020). Cellular Origins of Endometriosis: Towards Novel Diagnostics and Therapeutics. Seminars in Reproductive Medicine, 38(02/03), 201-215. https://doi.org/10.1055/s-0040-1713429

Goodwin, E., Abreu do Valle, H., Nitschke, A., Puyat, J., Yong, P. J., & Hanley, G. E. (2023). The Association Between Endometriosis Treatments and Depression and/or Anxiety in a Population-Based Pathologically Confirmed Cohort of People with Endometriosis. Women’s Health Reports, 4(1), 551–561. https://doi.org/10.1089/whr.2023.0068

Hamsah dan Nasrudin. (2019). Karakteristik Pasangan Infertil di BLU RS Dr. Wahidin Sudirohusodo Makassar. Green Medical Journal, vol. 1, no. 1, 2019, pp. 1-14, https://doi.org/10.33096/gmj.v1i1.15.

Indarwati, I., Hastuti, U.R., & Dewi, Y.L. (2017). Analysis of Factors Influencing Female Infertility. Journal of Maternal and Child Health 2(2): 150-161 https://doi.org/10.26911/thejmch.2017.02.02.06

Invitti, A. L., & Demetriou, L. (2023). Editorial: The impact of endometriosis. In Frontiers in Global Women’s Health (Vol. 4). Frontiers Media S.A. https://doi.org/10.3389/fgwh.2023.1190974

Iordăchescu, D. A., Paica, C. I., Boca, A. E., Gică, C., Panaitescu, A. M., Peltecu, G., Veduță, A., & Gică, N. (2021). Anxiety, difficulties, and coping of infertile women. Healthcare (Switzerland), 9(4). https://doi.org/10.3390/healthcare9040466

Jamhariyah, J., Dian, D., & Sasmito, L. (2022). Obesitas Dengan Kejadian Infertilitas Pada Wanita Usia Subur. Healthy : Jurnal Inovasi Riset Ilmu Kesehatan, 1(2), 121–131. https://doi.org/10.51878/healthy.v1i2.1246

Kamaryati, Ni & Malathum, Porntip. (2020). Family Support: A Concept Analysis. 403-411. https://www.researchgate.net/publication/343253776

Khan, S., & Lee, C. L. (2021). Treating Deep Endometriosis in Infertile Patients before Assisted Reproductive Technology. Gynecology and minimally invasive therapy, 10(4), 197–202. https://doi.org/10.4103/GMIT.GMIT_154_20

Koser, K. (2020). Fertility Counseling With Couples: A Theoretical Approach. The Family Journal, 28(1), 25-32. https://doi.org/10.1177/1066480719887498

Kurniawan dkk. (2020). Hubungan Kadar β-hCG 12 Hari Pasca Transfer Embryo dengan Luaran Kehamilan. Jurnal Kesehatan Reproduksi, 7(1), 1-5. https://doi.org/10.22146/jkr.53479

Lalami, I., Abo, C., Borghese, B., Chapron, C., & Vaiman, D. (2021). Genomics of endometriosis: From genome wide association studies to exome sequencing. In International Journal of Molecular Sciences (Vol. 22, Issue 14). MDPI. https://doi.org/10.3390/ijms22147297

Luqyana, S., & Moekroni, R. (2020). Diagnosis Dan Tatalaksana Terbaru Endometriosis. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 7(2), 67-75. https://doi.org/10.53366/jimki.v7i2.66

Marlinda, M., Afiyati, Y., & Budiati, T. (2018). Asuhan Keperawatan Pada Klien Dengan Kista Endometriosis Menggunakan Pendekatan Teori Comfort Dan Loss & Grief. Jurnal Kesehatan Panca Bhakti Lampung, 6(2), 117. https://doi.org/10.47218/jkpbl.v6i2.48

Matasariu, R. D., Mihaila, A., Iacob, M., Dumitrascu, I., Onofriescu, M., Crumpei Tanasa, I., & Vulpoi, C. (2017). Psycho-social aspects of quality of life in women with endometriosis. In Acta Endocrinologica (Vol. 13, Issue 3, pp. 334–339). Acta Endocrinologica Foundation. https://doi.org/10.4183/aeb.2017.334

Márki, G., Vásárhelyi, D., Rigó, A., Kaló, Z., Ács, N., & Bokor, A. (2022). Challenges of and possible solutions for living with endometriosis: a qualitative study. BMC Women’s Health, 22(1). https://doi.org/10.1186/s12905-022-01603-6

Mu, F., Rich-Edwards, J., Rimm, E. B., Spiegelman, D., Forman, J. P., & Missmer, S. A. (2017). Association between Endometriosis and Hypercholesterolemia or Hypertension. Hypertension, 70(1), 59–65. https://doi.org/10.1161/Hypertensionaha.117.09056

Nap, A., & de Roos, N. (2022). Endometriosis and the effects of dietary interventions: what are we looking for? Reproduction and Fertility, 3(2), C14–C22. https://doi.org/10.1530/RAF-21-0110

Nurhadhani dan Suzanna. (2022). Penerimaan Diri Wanita Infertilitas. Jurnal Psikologi Terapan (JPT), Vol 3, No.2 , 1-10.https://doi.org/10.29103/jpt.v3i2.8876

Pickett, C., Foster, W. G., & Agarwal, S. (2023). Current endometriosis care and opportunities for improvement. Reproduction & fertility, 4(3), e220091. Advance online publication. https://doi.org/10.1530/RAF-22-0091

Putri, P.M. (2021). Karakteristik Pasien Yang Menjalani Bayi Tabung Dengan Protokol Antagonis Di Klinik Bayi Tabung Rumah Sakit Umum Pusat Sanglah Tahun 2014 – 2017. E-Jurnal Medika Udayana.

René, C., Landry, I., & de Montigny, F. (2022). Couples’ experiences of pregnancy resulting from assisted reproductive technologies: A qualitative meta-synthesis. In International Journal of Nursing Studies Advances (Vol. 4). Elsevier B.V. https://doi.org/10.1016/j.ijnsa.2021.100059

Rooney, K. L., & Domar, A. D. (2018). The relationship between stress and infertility. Dialogues in Clinical Neuroscience, 20(1), 41–47. https://doi.org/10.31887/dcns.2018.20.1/klrooney

Shi, J., Tan, X., Feng, G., Zhuo, Y., Jiang, Z., Banda, S., Wang, L., Zheng, W., Chen, L., Yu, D., & Guo, C. (2023). Research advances in drug therapy of endometriosis. In Frontiers in Pharmacology (Vol. 14). Frontiers Media SA. https://doi.org/10.3389/fphar.2023.1199010

Škegro, B., Bjedov, S., Mikuš, M., Mustač, F., Lešin, J., Matijević, V., Ćorić, M., Elveđi Gašparović, V., Medić, F., & Sokol Karadjole, V. (2021). Endometriosis, Pain and Mental Health. Psychiatria Danubina, 33(Suppl 4), 632–636.

Smolarz, B., Szyłło, K., & Romanowicz, H. (2021). Endometriosis: Epidemiology, classification, pathogenesis, treatment and genetics (review of literature). International Journal of Molecular Sciences, 22(19). https://doi.org/10.3390/ijms221910554

Somigliana, E., Piani, L. L., Paffoni, A., Salmeri, N., Orsi, M., Benaglia, L., Vercellini, P., & Vigano’, P. (2023). Endometriosis and IVF treatment outcomes: unpacking the process. In Reproductive Biology and Endocrinology (Vol. 21, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s12958-023-01157-8

Suryoningrat dkk. (2021). Apakah Endometriosis Mempengaruhi Kualitas Embryo pada Pasien Invitro Fertilization?. Jurnal Kesehatan Reproduksi 8 (1), 1-5. https://doi.org/10.22146/jkr.63039

Szypłowska, M., Tarkowski, R., & Kułak, K. (2023). The impact of endometriosis on depressive and anxiety symptoms and quality of life: a systematic review. In Frontiers in Public Health (Vol. 11). Frontiers Media SA. https://doi.org/10.3389/fpubh.2023.1230303Taylor HS, P. L. (2020). Endometriosis. Philadelpia: Wolters Kluwer.

Vennberg Karlsson, J., Patel, H., & Premberg, A. (2020). Experiences of health after dietary changes in endometriosis: A qualitative interview study. BMJ Open, 10(2). https://doi.org/10.1136/bmjopen-2019-032321

Wulandari, D.R., Handono, B., Rachmawati, A., & Hidayat, D.R. (2020). Luaran Kehamilan pada Pasien dengan Infertilitas Berkaitan dengan Endometriosis, Infertilitas karena Faktor Tuba, dan Unexplained Infertility, setelah Menjalani Prosedur IVF / ICSI di Klinik Aster RSUP Dr. Hasan Sadikin Bandung. Indonesian Journal of Obstetrics & Gynecology Science.

Yang, J., Wen, Y., Li, D., Hou, X., Peng, B., & Wang, Z. (2023). Retrospective analysis of the endometrial preparation protocols for frozen-thawed embryo transfer cycles in women with endometriosis. Reproductive Biology and Endocrinology, 21(1). https://doi.org/10.1186/s12958-023-01132-3

Zandi, N., Behboodi Moghadam, Z., Hossein Rashidi, B., Namazi, M., & Haghani, S. (2023). Reproductive health of women with endometriosis: an improving educational intervention based on the planned behavior theory. Middle East Fertility Society Journal, 28(1). https://doi.org/10.1186/s43043-023-00129-7

Zondervan, K. T., Becker, C. M., & Missmer, S. A. (2020). Endometriosis. New England Journal of Medicine, 382(13), 1244–1256. https://doi.org/10.1056/NEJMra1810764

Zieliński, K., Drabczyk, D., Kunicki, M., Drzyzga, D., Kloska, A., & Rumiński, J. (2023). Evaluating the risk of endometriosis based on patients’ self-assessment questionnaires. Reproductive Biology and Endocrinology, 21(1). https://doi.org/10.1186/s12958-023-01156-9.

Downloads

Published

01/06/2024

How to Cite

Karim, U. N., Handayani, H., & Setyaningsih, W. (2024). Hubungan Demografi (Pendidikan, Pekerjaan) dan Faktor Determinan (Pola Makan, Genetik, Obat-Obatan, Psikososial) Pasien Endometriosis terhadap Keberhasilan Kehamilan Program Bayi Tabung. Jurnal Keperawatan, 16(4), 1165–1176. https://doi.org/10.32583/keperawatan.v16i4.2026