Hubungan Inflammatory Bowel Disease sebagai Risiko terjadinya Penyakit Parkinson
DOI:
https://doi.org/10.32583/keperawatan.v16i2.1714Keywords:
inflamasi, penyakit inflamasi usus, penyakit parkinsonAbstract
Parkinson’s disease (PD) adalah penyakit neurodegeneratif yang menyebabkan gangguan gerakan dengan prevalensi yang diperkirakan akan terus meningkat. Beberapa penelitian menunjukkan bahwa inflammatory bowel disease (IBD) dapat menjadi faktor risiko terjadinya PD. Memaparkan dan menganalisis hubungan antara IBD sebagai faktor risiko terjadinya PD. Penelusuran literatur dilakukan melalui Google Scholar, PubMed, SAGE, JSTOR, ProQuest, dan EBSCOhost, dengan kata kunci “inflammatory bowel disease”, “Parkinson’s disease”, dan “chronic intestinal inflammation”. Kriteria inklusi mencakup literatur orisinil dalam Bahasa Inggris yang meneliti hubungan IBD dengan PD. Pada studi ini didapatkan bahwa ditemukan hubungan antara IBD dan PD. Peningkatan risiko PD pada pasien dengan IBD dapat terkait dengan mekanisme inflamasi, gangguan gut-brain axis, penumpukan protein α-synuclein, dan mutasi gen LRRK2. Terapi antiinflamasi dapat digunakan untuk mencegah terjadinya PD pada pasien IBD. Sebagian besar studi menunjukkan adanya hubungan yang signifikan antara IBD dan PD.
References
Aarsland, D., Batzu, L., Halliday, G. M., Geurtsen, G. J., Ballard, C., Ray Chaudhuri, K., & Weintraub, D. (2021). Parkinson disease-associated cognitive impairment. Nature Reviews Disease Primers, 7(1). https://doi.org/10.1038/s41572-021-00280-3
Abramson, O., Durant, M., Mow, W., Finley, A., Kodali, P., Wong, A., Tavares, V., McCroskey, E., Liu, L., Lewis, J. D., Allison, J. E., Flowers, N., Hutfless, S., Velayos, F. S., Perry, G. S., Cannon, R., & Herrinton, L. J. (2010). Incidence, prevalence, and time trends of pediatric inflammatory bowel disease in Northern California, 1996 to 2006. Journal of Pediatrics, 157(2). https://doi.org/10.1016/j.jpeds.2010.02.024
Adamiak, T., Walkiewicz-Jedrzejczak, D., Fish, D., Brown, C., Tung, J., Khan, K., Faubion, W., Park, R., Heikenen, J., Yaffee, M., Rivera-Bennett, M. T., Wiedkamp, M., Stephens, M., Noel, R., Nugent, M., Nebel, J., Simpson, P., Kappelman, M. D., & Kugathasan, S. (2013). Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: A population-based epidemiological study. Inflammatory Bowel Diseases, 19(6), 1218–1223. https://doi.org/10.1097/MIB.0b013e318280b13e
Agrawal, M., & Jess, T. (2022). Implications of the changing epidemiology of inflammatory bowel disease in a changing world. In United European Gastroenterology Journal (Vol. 10, Issue 10, pp. 1113–1120). John Wiley and Sons Inc. https://doi.org/10.1002/ueg2.12317
Armstrong, M. J., & Okun, M. S. (2020). Diagnosis and Treatment of Parkinson Disease: A Review. In JAMA - Journal of the American Medical Association (Vol. 323, Issue 6, pp. 548–560). American Medical Association. https://doi.org/10.1001/jama.2019.22360
Berganzo, K., Tijero, B., González-Eizaguirre, A., Somme, J., Lezcano, E., Gabilondo, I., Fernandez, M., Zarranz, J. J., & Gómez-Esteban, J. C. (2016). Motor and non-motor symptoms of Parkinson’s disease and their impact on quality of life and on different clinical subgroups. Neurología (English Edition), 31(9), 585–591. https://doi.org/10.1016/j.nrleng.2014.10.016
Bialecka, M., Kurzawski, M., Klodowska-Duda, G., Opala, G., Juzwiak, S., Kurzawski, G., Tan, E. K., & Drozdzik, M. (2007). CARD15 variants in patients with sporadic Parkinson’s disease. Neuroscience Research, 57(3), 473–476. https://doi.org/10.1016/j.neures.2006.11.012
Braak, H., De Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006). Gastric α-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology. Neuroscience Letters, 396(1), 67–72. https://doi.org/10.1016/j.neulet.2005.11.012
Camacho-Soto, A., Gross, A., Searles Nielsen, S., Dey, N., & Racette, B. A. (2018). Inflammatory bowel disease and risk of Parkinson’s disease in Medicare beneficiaries. Parkinsonism and Related Disorders, 50, 23–28. https://doi.org/10.1016/j.parkreldis.2018.02.008
Church, P. C., Ho, S., Sharma, A., Tomalty, D., Frost, K., Muise, A., Walters, T. D., & Griffiths, A. M. (2019). Intensified Infliximab Induction is Associated with Improved Response and Decreased Colectomy in Steroid-Refractory Paediatric Ulcerative Colitis. Journal of Crohn’s and Colitis, 13(8), 982–989. https://doi.org/10.1093/ecco-jcc/jjz019
Clairembault, T., Leclair-Visonneau, L., Coron, E., Bourreille, A., Le Dily, S., Vavasseur, F., Heymann, M. F., Neunlist, M., & Derkinderen, P. (2015). Structural alterations of the intestinal epithelial barrier in Parkinson’s disease. Acta Neuropathologica Communications, 3, 12. https://doi.org/10.1186/s40478-015-0196-0
Freuer, D., & Meisinger, C. (2022). Association between inflammatory bowel disease and Parkinson’s disease: A Mendelian randomization study. Npj Parkinson’s Disease, 8(1). https://doi.org/10.1038/s41531-022-00318-7
Guan, Q. (2019). A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. Journal of Immunology Research, 2019. https://doi.org/10.1155/2019/7247238
Hedin, C. R., McCarthy, N. E., Louis, P., Farquharson, F. M., McCartney, S., Taylor, K., Prescott, N. J., Murrells, T., Stagg, A. J., Whelan, K., & Lindsay, J. O. (2014). Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn’s disease and their unaffected siblings. Gut, 63(10), 1578–1586. https://doi.org/10.1136/gutjnl-2013-306226
Kang, X., Ploner, A., Wang, Y., Ludvigsson, J. F., Williams, D. M., Pedersen, N. L., & Wirdefeldt, K. (2023). Genetic overlap between Parkinson’s disease and inflammatory bowel disease. Brain Communications, 5(1). https://doi.org/10.1093/braincomms/fcad002
Kim, G. H., Lee, Y. C., Kim, T. J., Kim, E. R., Hong, S. N., Chang, D. K., & Kim, Y. H. (2022). Risk of Neurodegenerative Diseases in Patients with Inflammatory Bowel Disease: A Nationwide Population-based Cohort Study. Journal of Crohn’s and Colitis, 16(3), 436–443. https://doi.org/10.1093/ecco-jcc/jjab162
Krawiec, P., & Pac-Kożuchowska, E. (2020a). Biomarkers and hematological indices in the diagnosis of iron deficiency in children with inflammatory bowel disease. Nutrients, 12(5). https://doi.org/10.3390/nu12051358
Krawiec, P., & Pac-Kożuchowska, E. (2020b). Biomarkers and hematological indices in the diagnosis of iron deficiency in children with inflammatory bowel disease. Nutrients, 12(5). https://doi.org/10.3390/nu12051358
Lee, H. S., Lobbestael, E., Vermeire, S., Sabino, J., & Cleynen, I. (2021). Inflammatory bowel disease and Parkinson’s disease: Common pathophysiological links. In Gut (Vol. 70, Issue 2, pp. 408–417). BMJ Publishing Group. https://doi.org/10.1136/gutjnl-2020-322429
Li, H. X., Zhang, C., Zhang, K., Liu, Y. Z., Peng, X. X., & Zong, Q. (2023). Inflammatory bowel disease and risk of Parkinson’s disease: evidence from a meta-analysis of 14 studies involving more than 13.4 million individuals. In Frontiers in Medicine (Vol. 10). Frontiers Media S.A. https://doi.org/10.3389/fmed.2023.1137366
Lin, J. C., Lin, C. S., Hsu, C. W., Lin, C. L., & Kao, C. H. (2016). Association between Parkinson’s disease and inflammatory bowel disease: A nationwide Taiwanese retrospective cohort study. Inflammatory Bowel Diseases, 22(5), 1049–1055. https://doi.org/10.1097/MIB.0000000000000735
Lippai, R., Veres-Székely, A., Sziksz, E., Iwakura, Y., Pap, D., Rokonay, R., Szebeni, B., Lotz, G., Béres, N. J., Cseh, Á., Szabó, A. J., & Vannay, Á. (2021). Immunomodulatory role of Parkinson’s disease 7 in inflammatory bowel disease. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-93671-1
Loosen, S. H., Yaqubi, K., May, P., Konrad, M., Gollop, C., Luedde, T., Kostev, K., & Roderburg, C. (2023). Association between Inflammatory Bowel Disease and Subsequent Development of Restless Legs Syndrome and Parkinson’s Disease: A Retrospective Cohort Study of 35,988 Primary Care Patients in Germany. Life, 13(4). https://doi.org/10.3390/life13040897
Martínez-Martín, P., Rodríguez-Blázquez, C., Alvarez, M., Arakaki, T., Arillo, V. C., Chaná, P., Fernández, W., Garretto, N., Martínez-Castrillo, J. C., Rodríguez-Violante, M., Serrano-Dueñas, M., Ballesteros, D., Rojo-Abuin, J. M., Chaudhuri, K. R., & Merello, M. (2015). Parkinson’s disease severity levels and MDS-Unified Parkinson’s Disease Rating Scale. Parkinsonism and Related Disorders, 21(1), 50–54. https://doi.org/10.1016/j.parkreldis.2014.10.026
Ng, S. C., Tang, W., Leong, R. W., Chen, M., Ko, Y., Studd, C., Niewiadomski, O., Bell, S., Kamm, M. A., De Silva, H. J., Kasturiratne, A., Senanayake, Y. U., Ooi, C. J., Ling, K. L., Ong, D., Goh, K. L., Hilmi, I., Ouyang, Q., Wang, Y. F., … Sung, J. J. Y. (2015). Environmental risk factors in inflammatory bowel disease: A population-based case-control study in Asia-Pacific. Gut, 64(7), 1063–1071. https://doi.org/10.1136/gutjnl-2014-307410
Noh, H., Jang, J., Kwon, S., Cho, S. Y., Jung, W. S., Moon, S. K., Park, J. M., Ko, C. N., Kim, H., & Park, S. U. (2020). The impact of korean medicine treatment on the incidence of parkinson’s disease in patients with inflammatory bowel disease: A nationwide population-based cohort study in South Korea. Journal of Clinical Medicine, 9(8), 1–17. https://doi.org/10.3390/jcm9082422
Ou, Z., Pan, J., Tang, S., Duan, D., Yu, D., Nong, H., & Wang, Z. (2021). Global Trends in the Incidence, Prevalence, and Years Lived With Disability of Parkinson’s Disease in 204 Countries/Territories From 1990 to 2019. Frontiers in Public Health, 9. https://doi.org/10.3389/fpubh.2021.776847
Park, S., Kim, J., Chun, J., Han, K., Soh, H., Kang, E. A., Lee, H. J., Im, J. P., & Kim, J. S. (2019). Patients with inflammatory bowel disease are at an increased risk of parkinson’s disease: A South Korean nationwide population-based study. Journal of Clinical Medicine, 8(8). https://doi.org/10.3390/jcm8081191
Peter, I., Dubinsky, M., Bressman, S., Park, A., Lu, C., Chen, N., & Wang, A. (2018). Anti-tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease. JAMA Neurology, 75(8), 939–946. https://doi.org/10.1001/jamaneurol.2018.0605
Pezzoli, G., & Cereda, E. (2013). Exposure to pesticides or solvents and risk of Parkinson disease. In Neurology (Vol. 80, Issue 22, pp. 2035–2041). https://doi.org/10.1212/WNL.0b013e318294b3c8
Pinel Ríos, J., Madrid Navarro, C. J., Pérez Navarro, M. J., Cabello Tapia, M. J., Piña Vera, M. J., Campos Arillo, V., Gómez García, M. R., Mínguez Castellanos, A., & Escamilla Sevilla, F. (2019). Association of Parkinson’s disease and treatment with aminosalicylates in inflammatory bowel disease: A cross-sectional study in a Spain drug dispensation records. BMJ Open, 9(6). https://doi.org/10.1136/bmjopen-2018-025574
Qiu, Y., Ren, W., Liu, Y., Chen, W. er, Pan, X. hua, & Ren, J. jing. (2020). Disease burden of inflammatory bowel disease in China from 1990 to 2017: Findings from the global burden of diseases 2017. EClinicalMedicine, 27. https://doi.org/10.1016/j.eclinm.2020.100544
Rogler, G., Singh, A., Kavanaugh, A., & Rubin, D. T. (2021). Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management. In Gastroenterology (Vol. 161, Issue 4, pp. 1118–1132). W.B. Saunders. https://doi.org/10.1053/j.gastro.2021.07.042
Rosen, M. J., Dhawan, A., & Saeed, S. A. (2015). Inflammatory bowel disease in children and adolescents. In JAMA Pediatrics (Vol. 169, Issue 11, pp. 1053–1060). American Medical Association. https://doi.org/10.1001/jamapediatrics.2015.1982
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., Chesselet, M. F., Keshavarzian, A., Shannon, K. M., Krajmalnik-Brown, R., Wittung-Stafshede, P., Knight, R., & Mazmanian, S. K. (2016). Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, 167(6), 1469-1480.e12. https://doi.org/10.1016/j.cell.2016.11.018
Taslim Pinzon, R., & Al Jody, A. (2019). Prevalensi Gejala Gangguan Gastrointestinal Pada Pasien Penyakit Parkinson Prevalence Of Gastrointestinal Symptoms On Parkinson’s Disease Patients At Bethesda Hospital, Yogyakarta. In JURNAL KEDOKTERAN YARSI (Vol. 27, Issue 1).
Van Den Eeden, S. K., Tanner, C. M., Bernstein, A. L., Fross, R. D., Leimpeter, A., Bloch, D. A., & Nelson, L. M. (2003). Incidence of Parkinson’s disease: Variation by age, gender, and race/ethnicity. American Journal of Epidemiology, 157(11), 1015–1022. https://doi.org/10.1093/aje/kwg068
Villarán, R. F., Espinosa-Oliva, A. M., Sarmiento, M., De Pablos, R. M., Argüelles, S., Delgado-Cortés, M. J., Sobrino, V., Van Rooijen, N., Venero, J. L., Herrera, A. J., Cano, J., & MacHado, A. (2010). Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: Potential risk factor in Parkinson’s disease. Journal of Neurochemistry, 114(6), 1687–1700. https://doi.org/10.1111/j.1471-4159.2010.06879.x
Villumsen, M., Aznar, S., Pakkenberg, B., Jess, T., & Brudek, T. (2019). Inflammatory bowel disease increases the risk of Parkinson’s disease: A Danish nationwide cohort study 1977-2014. Gut, 68(1), 18–24. https://doi.org/10.1136/gutjnl-2017-315666
Wang, H., Zhang, S., Yu, Q., Yang, G., Guo, J., Li, M., Zeng, Z., He, Y., Chen, B., & Chen, M. (2016). Circulating MicroRNA223 is a new biomarker for inflammatory bowel disease. Medicine (United States), 95(5). https://doi.org/10.1097/MD.0000000000002703
Wang, Y. F., Ou-Yang, Q., Xia, B., Liu, L. N., Gu, F., Zhou, K. F., Mei, Q., Shi, R. H., Ran, Z. H., Wang, X. Di, Hu, P. J., Wu, K. C., Liu, X. G., Miao, Y. L., Han, Y., Wu, X. P., He, G. B., Zhong, J., & Liu, G. J. (2013). Multicenter case-control study of the risk factors for ulcerative colitis in china. World Journal of Gastroenterology, 19(11), 1827–1833. https://doi.org/10.3748/wjg.v19.i11.1827
Weimers, P., Halfvarson, J., Sachs, M. C., Saunders-Pullman, R., Ludvigsson, J. F., Peter, I., Burisch, J., & Olén, O. (2019). Inflammatory bowel disease and Parkinson’s disease: A nationwide swedish cohort study. Inflammatory Bowel Diseases, 25(1), 111–123. https://doi.org/10.1093/ibd/izy190
Yan, S. L. S., Russell, J., & Granger, D. N. (2014). Platelet activation and platelet-leukocyte aggregation elicited in experimental colitis are mediated by interleukin-6. Inflammatory Bowel Diseases, 20(2), 353–362. https://doi.org/10.1097/01.MIB.0000440614.83703.84.
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