Penurunan Nyeri dan Kekakuan Sendi Menggunakan Extra Virgin Olive Oil Topikal pada Osteoarthritis Lutut
DOI:
https://doi.org/10.32583/keperawatan.v15i4.1152Keywords:
extra virgin olive oil, kekakuan sendi, nyeri, osteoarthritis lututAbstract
Nyeri dan kekakuan sendi merupakan gejala utama yang sering terjadi pada pasien osteoarthritis (OA) lutut. Terapi komplementer dan alternatif diperlukan untuk menurunkan tingkat nyeri dan kekakuan sendi pada OA lutut tanpa efek samping. Penelitian ini bertujuan untuk mengidentifikasi Extra Virgin Olive Oil (EVOO) topikal terhadap nyeri dan kekakuan sendi pada pasien OA lutut. Desain penelitian menggunakan quasi-experimental menggunakan pre-test and post-test dengan kelompok kontrol. Jumlah sampel terdiri dari 15 responden pada masing-masing kelompok intervensi (EVOO topikal) dan kelompok kontrol (placebo) dengan teknik consecutive sampling. Uji statistik dilakukan menggunakan uji parametrik (pooled t-test dan paired t-test) dan uji non parametrik (Mann-Whitney test dan Wilcoxon test) sesuai hasil uji normalitas. Hasil penelitian menunjukkan EVOO topikal menunjukan sedikit lebih berefek dalam menurunkan tingkat nyeri sesudah intervensi (hari ke-7 dan hari ke-14) dan kekakuan sendi pada hari ke-14 dibandingkan placebo (p < 0,05). Kesimpulan penelitian ini menunjukkan bahwa EVOO topikal secara bertahap menurunkan nyeri dan kekakuan sendi pada pasien OA lutut. Oleh karena itu, EVOO topikal direkomendasikan sebagai terapi komplementer dan alternatif yang aman tanpa efek samping pada pasien OA lutut.
References
Abbasifard, M., Bazzaz, A., Bazmandegan, G., Rezaeian, M., Saeedaskari, P., Mahmoodian, H., & Zareshahi, R. (2020). Effect of topical chickpea oil (Cicer arietinum L.) on knee osteoarthritis: A randomized double-blind controlled clinical trial. European Journal of Integrative Medicine, 35, 101076.
Aboulenain, S., & Saber, A. Y. (2023). Primary Osteoarthritis.
Almalty, A.-M., Jebril, M., Abu Tariah, H., & S, B. (2014). The Effect of Paraffin Wax and Exercise vs. Exercise Treatment on Keyboard User’s Hands Pain and Strength. Indian Journal of Physiotherapy and Occupational Therapy, 8, 170–175.
Ansari, M. Y., Ahmad, N., & Haqqi, T. M. (2020). Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 129, 110452. https://doi.org/10.1016/j.biopha.2020.110452
Ayu Diah Oktavia, Rise Desnita, D. S. A., & Program. (2021). POTENSI PENGGUNAAN MINYAK ZAITUN (Olive Oil) SEBAGAI PELEMBAB. Program Studi Farmasi, Fakultas Kedokteran, Universitas Tanjungpura.
Cui, A., Li, H., Wang, D., Zhong, J., Chen, Y., & Lu, H. (2020). Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine, 29–30, 100587. https://doi.org/10.1016/j.eclinm.2020.100587
Elmowafy, M., Musa, A., Alnusaire, T. S., Shalaby, K., Fouda, M. M. A., Salama, A., Al-Sanea, M. M., Abdelgawad, M. A., Gamal, M., & Fouad, S. A. (2021). Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability. Polymers, 13(11). https://doi.org/10.3390/polym13111808
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., Lamuela-Raventos, R. M., Serra-Majem, L., Pintó, X., Basora, J., Muñoz, M. A., Sorlí, J. V, Martínez, J. A., Fitó, M., Gea, A., … Martínez-González, M. A. (2018). Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. The New England Journal of Medicine, 378(25), e34. https://doi.org/10.1056/NEJMoa1800389
Fazeli, G., Levin-konigsberg, R., Bassik, M. C., Stigloher, C., & Wehman, A. M. (2023). Article A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes ll A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Current Biology, 33(4), 607-621.e7. https://doi.org/10.1016/j.cub.2022.12.041
García-López, J., Polanco-García, M., & Montes, A. (2021). Factors Associated With the Risk of Developing Moderate to Severe Acute Postoperative Pain After Primary Total Knee Arthroplasty: Results From the PAIN OUT Registry. Journal of Arthroplasty, 36(6), 1966–1973. https://doi.org/10.1016/j.arth.2021.02.005
Gelmini, F., Ruscica, M., Macchi, C., Bianchi, V., Facino, R. M., Beretta, G., & Magni, P. (2015). Unsaponifiable Fraction of Unripe Fruits of Olea europaea: An Interesting Source of Anti-inflammatory Constituents. Planta Medica, 82, 273–278.
Haroyan, A., Mukuchyan, V., Mkrtchyan, N., Minasyan, N., Gasparyan, S., Sargsyan, A., Narimanyan, M., & Hovhannisyan, A. (2018). Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complementary and Alternative Medicine, 18(1), 7. https://doi.org/10.1186/s12906-017-2062-z
Hekmatpou, D., Mortaji, S., Rezaei, M., & Shaikhi, M. (2020). The Effectiveness of Olive Oil in Controlling Morning Inflammatory Pain of Phalanges and Knees Among Women With Rheumatoid Arthritis: A Randomized Clinical Trial. Rehabilitation Nursing Journal, 45(2). https://journals.lww.com/rehabnursingjournal/Fulltext/2020/03000/The_Effectiveness_of_Olive_Oil_in_Controlling.8.aspx
Kementerian Kesehatan Republik Indonesia. (2018). Laporan Nasional Riset Kesehatan Dasar. Kementerian Kesehatan RI, 1–582.
Marrone, G., Urciuoli, S., Lauro, M. Di, Ruzzolini, J., Ieri, F., Vignolini, P., Daniele, F. Di, Guerriero, C., Nediani, C., Daniele, N. Di, & Noce, A. (2022). Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease. 1–19.
Nieto, F. R., Cobos, E. J., Entrena, J. M., Parra, A., García-Granados, A., & Baeyens, J. M. (2013). Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. Journal of Natural Products, 76(4), 737–740. https://doi.org/10.1021/np300783a
Notoatmodjo S. (2018). Metodologi Penelitian Kesehatan. Rineka Cipta.
Nsir, H., Taamalli, A., Valli, E., Bendini, A., Toschi, T. G., & Zarrouk, M. (2017). Chemical Composition and Sensory Quality of Tunisian ‘Sayali’ Virgin Olive Oils as Affected by Fruit Ripening: Toward an Appropriate Harvesting Time. Journal of the American Oil Chemists’ Society, 94, 913–922.
Nursalam. (2021). Metodelogi penelitian (1st ed.). Gramedia.
Sadat, S., Esfahani, S., Omidian, M., Choopani, R., Mahlooji, K., Riahi, S. M., Chaichi, M., & Khodadoost, M. (2020). Investigating the effect of traditional Iranian massage (Kermanshahi style) on the clinical symptoms of knee osteoarthritis. Archives of Pharmacy Practice, 11.
Santangelo, C., Varì, R., Scazzocchio, B., De Sancti, P., Giovannini, C., D`Archivio, M., & Masella, R. (2017). Anti-inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases? Endocrine, Metabolic & Immune Disorders - Drug Targets, 18(1), 36–50. https://doi.org/10.2174/1871530317666171114114321
Singh, P. P., & Saldaña, M. D. A. (2011). Subcritical water extraction of phenolic compounds from potato peel. Food Research International, 44(8), 2452–2458. https://doi.org/10.1016/j.foodres.2011.02.006
Visioli, F., Davalos, A., López de Las Hazas, M.-C., Crespo, M. C., & Tomé-Carneiro, J. (2020). An overview of the pharmacology of olive oil and its active ingredients. British Journal of Pharmacology, 177(6), 1316–1330. https://doi.org/10.1111/bph.14782
Wilbert, C. J., & Wilbert, J. (2018). Effectiveness of Olive Oil Application on Knee Pain among Patients with Osteoarthritis in Selected Hospital at Nagercoil Johny.
Zhang, L., Xing, R., Huang, Z., Ding, L., Zhang, L., Li, M., Li, X., Wang, P., & Mao, J. (2021). Synovial Fibrosis Involvement in Osteoarthritis. Frontiers in Medicine, 8, 684389. https://doi.org/10.3389/fmed.2021.684389
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Jurnal Keperawatan
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
