Colchicine from Gout to Covid-19
Keywords:
colchicine, covid-19, goutAbstract
Colchicine merupakan alkaloid toksik dan karsinogenik yang diperoleh dari ekstrak tumbuhan Colchium autumnale dan telah digunakan untuk mengobati radang sendi (gout) selama berabad-abad. Hasil uji klinis menunjukkan bahwa colchicine dosis rendah efektif untuk penatalaksanaan gout akut serta untuk profilkasis pemeliharaan jangka panjang dan penggunaan colchicine diketahui mengurangi gejala respon inflamasi yang berkaitan dengan COVID-19 dan mengurangi frekuensi manifestasi lain seperti infiltrat paru, sakit kepala dan artralgia. Namun, sejauh ini penelitian telah menunjukkan bahwa colchicine tidak digunakan sebagai pengobatan awal atau primer untuk mengobati COVID-19 tetapi sebagai pengobatan yang “off-label” sebagai respons terhadap hiper-inflamasi yang disebabkan oleh pelepasan sitokin.
References
Abanonu GB, Daskin A, Akdogan MF, Uyar S, Demirtunc R. Mean platelet volume and β-thromboglobulin levels in familial mediterranean fever: Effect of colchicine use? Eur J Intern Med. 2012;
Asako H, Kubes P, Baethge BA, Wolf RE, Granger DN. Colchicine and methotrexate reduce leukocyte adherence and emigration in rat mesenteric venules. Inflammation. 1992;
Bhattacharyya B, Panda D, Gupta S, Banerjee M. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin. Medicinal Research Reviews. 2008.
Borstad GC, Bryant LR, Abel MP, Scroggie DA, Harris MD, Alloway JA. Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis. J Rheumatol. 2004;
Bozkurt D, Bicak S, Sipahi S, Taskin H, Hur E, Ertilav M, et al. The effects of colchicine on the progression and regression of encapsulation peritoneal sclerosis. Perit Dial Int. 2008;
Charpentier MS, Whipple RA, Vitolo MI, Boggs AE, Slovic J, Thompson KN, et al. Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment. Cancer Res. 2014;
Chia EW, Grainger R, Harper JL. Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicine. Br J Pharmacol. 2008;
Cronstein BN, Molad Y, Reibman J, Balakhane E, Levin RI, Weissmann G. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest. 1995;
Cronstein BN, Sunkureddi P. Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis. Journal of Clinical Rheumatology. 2013.
Cumhur Cure M, Kucuk A, Cure E. Colchicine may not be effective in COVID-19 infection; it may even be harmful? Clinical Rheumatology.2020.
Deftereos S, Giannopoulos G, Vrachatis DA, Siasos G, Giotaki SG, Cleman M, et al. Colchicine as a potent anti-inflammatory treatment in COVID-19: can we teach an old dog new tricks? Eur Hear journal Cardiovasc Pharmacother. 2020;
Della-Torre E, Della-Torre F, Kusanovic M, Scotti R, Ramirez GA, Dagna L, et al. Treating COVID-19 with colchicine in community healthcare setting. Clinical Immunology. 2020.
Fordham JN, Kirwan J, Cason J, Currey HLF. Prolonged reduction in polymorphonuclear adhesion following oral colchicine. Ann Rheum Dis. 1981;
Gagné V, Marois L, Levesque JM, Galarneau H, Lahoud MH, Caminschi I, et al. Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: Potential therapeutic implications. Arthritis Res Ther. 2013;
Ganguly A, Yang H, Zhang H, Cabral F, Patel KD. Microtubule dynamics control tail retraction in migrating vascular endothelial cells. Mol Cancer Ther. 2013;
Gendelman O, Amital H, Bragazzi NL, Watad A, Chodick G. Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis. Autoimmunity Reviews. 2020.
Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, et al. Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. Am J Physiol - Ren Physiol. 2013;
Hamburger M, Baraf HSB, Adamson TC, Basile J, Bass L, Cole B, et al. 2011 recommendations for the diagnosis and management of gout and hyperuricemia. Physician and Sportsmedicine. 2011.
Huang C, Cen C, Wang C, Zhan H, Ding X. Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia. Lipids Health Dis. 2014;
Keikhaei B, Bahadoram M, Rajaei E, Alikhani K, Helalinasab A. Possible ameliorative effect of colchicine on the prevention of cytokine storm and its associated hyper-inflammation in patients with COVID-19. J Prev Epidemiol. 2020;
Khanna D, Khanna PP, Fitzgerald JD, Singh MK, Bae S, Neogi T, et al. 2012 American college of rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res. 2012;
Korkmaz S, Erturan I, NazIroǧlu M, Uǧuz AC, Çiǧ B, Övey IS. Colchicine modulates oxidative stress in serum and neutrophil of patients with Behçet disease through regulation of Ca 2+ release and antioxidant system. J Membr Biol. 2011;
Leung YY, Yao Hui LL, Kraus VB. Colchicine-Update on mechanisms of action and therapeutic uses. Seminars in Arthritis and Rheumatism. 2015.
Li C, Yang CW, Ahn HJ, Kim WY, Park CW, Park JH, et al. Colchicine decreases apoptotic cell death in chronic cyclosporine nephrotoxicity. J Lab Clin Med. 2002;
Maldonado EN, Patnaik J, Mullins MR, Lemasters JJ. Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res. 2010;
Marin-Esteban V, Charron D, Gelin C, Mooney N. Chemotherapeutic agents targeting the tubulin cytoskeleton modify lps-induced cytokine secretion by dendritic cells and increase antigen presentation. J Immunother. 2010;
Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;
Maurizi M, Delorme N, Laprévote-Heully MC, Lambert H, Larcan A. Syndrome de détresse respiratoire aiguë de l’adulte au cours des intoxications par la colchicine. Ann Fr Anesth Reanim. 1986;
Meshki J, Douglas SD, Hu M, Leeman SE, Tuluc F. Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner. PLoS One. 2011;
Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013;
Mizumoto N, Gao J, Matsushima H, Ogawa Y, Tanaka H, Takashima A. Discovery of novel immunostimulants by dendritic-cell-based functional screening. Blood. 2005;
Mizumoto N, Tanaka H, Matsushima H, Vishwanath M, Takashima A. Colchicine promotes antigen cross-presentation by murine dendritic cells [5]. Journal of Investigative Dermatology. 2007.
Montealegre-Gómez G, Garavito E, Gómez-López A, Rojas-Villarraga A, Parra-Medina R. Colchicine: A potential therapeutic tool against COVID-19. Experience of 5 patients. Reumatol Clin. 2020;
New York State Medicaid Drug Information Response Center. Could colchicine be effective for treatment of COVID-19?. 2020.
Nicola Dalbeth, MD1; Thomas J. Lauterio, PhD, MBA2; and Henry R. Wolfe, PhD. Mechanism of Action of Colchicine in the Treatment of Gout. 2014
Nuki G. Colchicine: Its mechanism of action and efficacy in crystal-induced inflammation. Current Rheumatology Reports. 2008.
Paschke S, Weidner AF, Paust T, Marti O, Beil M, Ben-Chetrit E. Technical Advance: Inhibition of neutrophil chemotaxis by colchicine is modulated through viscoelastic properties of subcellular compartments. J Leukoc Biol. 2013;
Pascual E, Castellano JA. Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals. J Rheumatol. 1992;
Peachman KK, Rao M, Palmer DR, Zidanic M, Sun W, Alving CR, et al. Functional microtubules are required for antigen processing by macrophages and dendritic cells. Immunol Lett. 2004;
Phelps P. Polymorphonuclear leukocyte motility in vitro IV colchicine inhibition of chemotactic activity formation after phagocytosis of urate crystals. Arthritis Rheum. 1970;
Roberge CJ, Gaudry M, de Medicis R, Lussier A, Poubelle PE, Naccache PH. Crystal-induced neutrophil activation. IV. Specific inhibition of tyrosine phosphorylation by colchicine. J Clin Invest. 1993;
Ryckman C, McColl SR, Vandal K, De Médicis R, Lussier A, Poubelle PE, et al. Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Arthritis Rheum. 2003;
Sandbo N, Ngam C, Torr E, Kregel S, Kach J, Dulin N. Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2. J Biol Chem. 2013;
Shu JC, He YJ, Lv X, Ye GR, Wang LX. Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells. J Nat Med. 2009;
Taskiran EZ, Cetinkaya A, Balci-Peynircioglu B, Akkaya YZ, Yilmaz E. The effect of colchicine on pyrin and pyrin interacting proteins. J Cell Biochem. 2012;
Terekeci HM, Oktenli C, Ozgurtas T, Nalbant S, Top C, Celik S, et al. Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF? J Rheumatol. 2008;35(10):2024–2029.
Terkeltaub RA, Furst DE, Bennett K, Kook KA, Crockett RS, Davis MW. High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study. Arthritis Rheum. 2010;
Terkeltaub RA, Furst DE, Digiacinto JL, Kook KA, Davis MW. Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors. Arthritis Rheum. 2011;63(8):2226–2237.
Terkeltaub RA. Colchicine update: 2008. Semin Arthritis Rheum. 2009;38(6):411–419.
U.S. Food and Drug Administration, online. [Accessed 20 Dec. 2013]; Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm174315.htm.
Wortmann RL, MacDonald PA, Hunt B, Jackson RL. Effect of Prophylaxis on Gout Flares After the Initiation of Urate-Lowering Therapy: Analysis of Data From Three Phase III Trials. Clin Ther. 2010;
Yu JW, Farias A, Hwang I, Fernandes-Alnemri T, Alnemri ES. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome. J Biol Chem. 2013;
Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clinical Immunology. 2020.
Widiyanto, A., Murti, B., & Soemanto, R. B. (2018). Multilevel analysis on the Socio-Cultural, lifestyle factors, and school environment on the risk of overweight in adolescents, Karanganyar district, central Java. Journal of Epidemiology and Public Health, 3(1), 94-104.
World Health Organization. Clinical Management of COVID-19. 2020.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
