Analisis Penggunaan Indeks Gizi Prognostik pada Kesintasan Keseluruhan Pasien Kanker Payudara

Authors

  • Fitri Sofiatin Universitas Mitra Indonesia
  • Sugeng Eko Irianto Universitas Mitra Indonesia
  • Bambang Setiaji Universitas Mitra Indonesia
  • Aila Karyus Universitas Mitra Indonesia

DOI:

https://doi.org/10.32583/pskm.v14i2.1905

Keywords:

albumin, indeks gizi prognostik, kanker payudara, kesintasan, limfosit

Abstract

Indeks gizi prognostik, dihitung melalui formula sederhana menggunakan kadar albumin serum dan jumlah sel limfosit dalam darah tepi. PNI telah dilaporkan terkait dengan efek terapeutik. Penelitian ini bertujuan untuk mengetahui hubungan antara nilai indeks gizi prognostik dengan kesintasan keseluruhan pasien kanker payudara. Penelitian observasional analitik yang berfokus pada analisis kesintasan pasien kanker payudara di RSUD Abdul Moeloek, Provinsi Lampung tahun 2018 dengan Keterangan Kelaikan Etik No. S.25/019/FKES10/2023 pada tanggal 15 Februari 2023 yang di keluarkan oleh Universitas Mitra Indonesia. Sampel terdapat 159 pasien kanker payudara menggunakan purposive sampling. Data dianalisis multivariat dengan uji regresi logistik ganda.  Hasil penelitian terdapat 6 pasien meninggal (3,75%) dan 153 pasien (96,25%) bertahan. Nilai rerata PNI pada pasien kanker payudara yaitu 70,0175 dengan PNI <45 sebanyak 44 orang dan PNI >45. Hasil kesintasan keseluruhan pasien kanker payudara yang memiliki nilai indeks gizi prognostik lebih dari 45 sebanyak 90,7%. Data menunjukkan bahwa terdapat hubungan antara PNI terhadap kesintasan keseluruhan 5 tahun dengan nilai p 0,046 dengan OR 0,171 dimana pasien dengan PNI <45 berisiko memiliki kesintasan < 5 tahun 0,171 kali lebih besar. Kesintasan keseluruhan pasien kanker payudara dalam 5 tahun sebanyak 96,25%. Terdapat hubungan indeks gizi prognostik dengan kesintasan keseluruhan pasien kanker payudara.

References

Beirer, A. 2021. Malnutrition and cancer, diagnosis and treatment. Memo - Magazine of European Medical Oncology, 14(2), 168–173. https://doi.org/10.1007/s12254-020-00672-3

Bray, F., Ferlay, J., & Soerjomataram, I. 2018. Global Cancer Statistics 2018 : GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin, 68, 394–424. https://doi.org/10.3322/caac.21492

Chen, L., Bai, P., Kong, X., Huang, S., Wang, Z., Wang, X., Fang, Y., & Wang, J. 2021. Prognostic Nutritional Index (PNI) in Patients With Breast Cancer Treated With Neoadjuvant Chemotherapy as a Useful Prognostic Indicator. Frontiers in Cell and Developmental Biology, 9(March). https://doi.org/10.3389/fcell.2021.656741

de Freitas Júnior, R., Nunes, R. D., Martins, E., Curado, M. P., Freitas, N. M. A., Soares, L. R., & Oliveira, J. C. 2017. Fatores prognósticos do câncer de mama e sobrevida global em cinco e dez anos na cidade de Goiânia, Brasil: Estudo de base populacional. Revista Do Colegio Brasileiro de Cirurgioes, 44(5), 435–443. https://doi.org/10.1590/0100-69912017005003

De Souza, M. C., Cruz, O. G., & Vasconcelos, A. G. G. 2016. Factors associated with disease-specific survival of patients with non-small cell lung cancer. Jornal Brasileiro de Pneumologia, 42(5), 317–325. https://doi.org/10.1590/S1806-37562015000000069

Deanasa, R. S., Umar, M., & Fitri, A. D. 2022. Overall Survival for Stage III Breast Cancer Patients at DR. Mohammad Hoesin General Hospital Palembang and the Influencing Factors. Indonesian Journal of Cancer, 16(4), 231. https://doi.org/10.33371/ijoc.v16i4.905

Dong, G., Wang, D., Liang, X., Gao, H., Wang, L., Yu, X., & Liu, J. 2014. Factors related to survival rates for breast cancer patients. International Journal of Clinical and Experimental Medicine, 7(10), 3719–3724.

Elobaid, Y., Aamir, M., Id, M. G., Suliman, A., Attoub, S., Mousa, H., Id, L. A. A., & Oulhaj, A. 2021. Breast cancer survival and its prognostic factors in the United Arab Emirates : A retrospective study. PLoS ONE, 1–10. https://doi.org/10.1371/journal.pone.0251118

Gebremeskel, K., & Genet, S. 2020. Assessment of Malnutrition among Female Breast Cancer Patients using Biochemical Markers. 5(2).

Gondhowiardjo, S., Christina, N., Ganapati, N. P. D., Hawariy, S., & Radityamurti, F. 2020. Five-Year Cancer Epidemiology at the National Referral Hospital : Hospital-Based Cancer Registry Data in Indonesia original reports abstract.

Hadiyati, F., Supriastuti, R., & Mujiharti, A. 2021. The Effect of Dietary Modification and Nutritional Education on Nutrition Care Process (NCP) for Increasing Dietary Intake, Body Weight, and Nutritional Status of Cancer Patients at Risk of Malnutrition and Malnourished in the Inpatient of Dharmais Cancer. Indonesian Journal of Cancer, 15(2), 69. https://doi.org/10.33371/ijoc.v15i2.768

Hu, G., Ding, Q., Zhong, K., Wang, S., Wang, S., & Huang, L. 2023. Low pretreatment prognostic nutritional index predicts poor survival in breast cancer patients: A meta-analysis. PLoS ONE, 18(1 January), 1–10. https://doi.org/10.1371/journal.pone.0280669

Hua, X., Long, Z. Q., Huang, X., Deng, J. P., He, Z. Y., Guo, L., Zhang, W. W., & Lin, H. X. 2020. The Value of Prognostic Nutritional Index (PNI) in Predicting Survival and Guiding Radiotherapy of Patients With T1-2N1 Breast Cancer. Frontiers in Oncology, 9(January), 1–8. https://doi.org/10.3389/fonc.2019.01562

Koseci, T., Bulut, G., Ata, S., Bayram, E., Cil, T., & Eser, K. 2022. Importance of Prognostic Nutritional Index in Patients with Metastatic Breast Cancer Treated with Trastuzumab Emtansine. Eurasian Journal of Medical Investigation, 6(4), 484–490. https://doi.org/10.14744/ejmi.2022.90000

Kumar, S., & Preetha, G. S. 2012. Health promotion: An effective tool for global health. Indian Journal of Community Medicine, 37(1), 5–12. https://doi.org/10.4103/0970-0218.94009

Mahmood, H., Faheem, M., Mahmood, S., Sadiq, M., & Irfan, J. 2015. Impact of age, tumor size, lymph node metastasis, stage, receptor status and menopausal status on overall survival of breast cancer patients in Pakistan. Asian Pacific Journal of Cancer Prevention, 16(3), 1019–1024. https://doi.org/10.7314/APJCP.2015.16.3.1019

Mohri, T., Mohri, Y., Shigemori, T., Takeuchi, K., Itoh, Y., & Kato, T. 2016. Impact of prognostic nutritional index on long-term outcomes in patients with breast cancer. World Journal of Surgical Oncology, 14(1), 1–6. https://doi.org/10.1186/s12957-016-0920-7

National Comprehensive Cancer Network. 2020. NCCN Clinical Practice Guidelines in Oncology: Breast Cancer.

Nurhayati, N., Arifin, Z., & Hardono, H. 2019. Analisis Faktor-Faktor Yang Berhubungan Dengan Kejadian Kanker Payudara. Holistik Jurnal Kesehatan, 13(2), 172–183. https://doi.org/10.33024/hjk.v13i2.1052

Oba, T., Maeno, K., Takekoshi, D., Ono, M., Ito, T., Kanai, T., & Ito, K. I. 2020. Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer. BMC Cancer, 20(1), 1–10. https://doi.org/10.1186/s12885-020-6647-4

Prasetyowati, & Katharina, K. 2014. Faktor-Faktor Yang Berhubungan Dengan Kejadian Kanker. VII(1), 75–84.

Sun, K., Chen, S., Xu, J., Li, G., & He, Y. 2014. The prognostic significance of the prognostic nutritional index in cancer: A systematic review and meta-analysis. Journal of Cancer Research and Clinical Oncology, 140(9), 1537–1549. https://doi.org/10.1007/s00432-014-1714-3

The Global Cancer Observatory. 2020. Cancer Incident in Indonesia. International Agency for Research on Cancer, 858, 1–2. https://gco.iarc.fr/

van de Worp, W. R. P. H., Schols, A. M. W. J., Theys, J., van Helvoort, A., & Langen, R. C. J. 2020. Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models. Frontiers in Nutrition, 7(December), 1–16. https://doi.org/10.3389/fnut.2020.601329

Wang, Y., Battseren, B., Yin, W., Lin, Y., Zhou, L., Yang, F., Wang, Y., Sun, L., & Lu, J. 2019. Predictive and prognostic value of prognostic nutritional index for locally advanced breast cancer. Gland Surgery, 8(6), 618–626. https://doi.org/10.21037/gs.2019.10.08

Downloads

Published

2023-12-01

How to Cite

Sofiatin, F., Irianto, S. E., Setiaji, B., & Karyus, A. . (2023). Analisis Penggunaan Indeks Gizi Prognostik pada Kesintasan Keseluruhan Pasien Kanker Payudara. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 14(2), 837–848. https://doi.org/10.32583/pskm.v14i2.1905