Systematic Review Children's Immunity Response to Covid-19 Infection

Authors

  • Yuly Peristiowati Department of Nursing, Institut Ilmu Kesehatan STRADA Indonesia
  • Semi Semi Faculty of Public Health, Institut Ilmu Kesehatan STRADA Indonesia

DOI:

https://doi.org/10.32583/keperawatan.v14i1.47

Keywords:

children, COVID-19, immune response

Abstract

Immunity is resistance from infection and the immune response is the coordination of cells in the body and other molecules against infection. Corona Virus is a positive chain Ribonucleic acid (RNA) virus whose transmission occurs more often from infected closest relatives with the main route through inhalation. direct respiratory droplets from coughing and sneezing. This systematic review aims to identify the immune response of children infected with Covid-19. Search articles using 4 databases, namely Scopus, ProQuest, Pubmed, and Science Direct using keywords and Boolean operators. Strategy to find articles using PICO. The results obtained 14 articles, assessment using PRISMA checklist.The results of the review show that SARS-CoV-2 infection in children triggers non-specific and specific immune responses. The non-specific immune response begins with an increase in white blood cells and triggers a specific immune response, namely T and B cells that will produce antibodies. There are increased levels of CRP, IL-6, IL-10, IFN-g,TNF-a and IP-10 which can be an independent predictor of disease severity. Excessive levels of mediators can causes a cytokine storm that damage the human body and increased D-dimer in severe cases. The specific immune response will mediate the formation of antibodies. B cells are assisted by T cells to differentiate into plasma cells, which then produce specific antibodies for viral antigens, in the form of IgM which is detected early and is then replaced by IgG. To improve the performance of the immune system, there needs to be an increase in nutrition, adequate rest, support and family motivation.

References

Chen, G. et al. (2020) 'Clinical and immunological features of severe and moderate coronavirus disease 2019', The Journal of clinical investigation. Am Soc Clin Investig, 130(5).

Chowdhury, MA et al. (2020) 'Immune response in COVID-19: A review', Journal of Infection and Public Health. King Saud Bin Abdulaziz University for Health Sciences, 13, pp. 1619–1629. doi: 10.1016/j.jiph.2020.07.001.

Diorio, C. et al. (2020) 'Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2', Journal of Clinical Investigation, 130(11), pp. 5967–5975. doi:10.1172/JCI140970.

Dong, Y. et al. (2020) 'Epidemiology of COVID-19 among children in China', Pediatrics. Am Acad Pediatrics, 145(6).

Du, H. et al. (2020) 'Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status', Allergy: European Journal of Allergy and Clinical Immunology, 76(2), pp. 510–532. doi: 10.1111/all.14452.

Du, W. et al. (2020) 'Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China', Infection. Springer Berlin Heidelberg, 48(3), pp. 445–452. doi:10.1007/s15010-020-01427-2.

Gadotti, AC et al. (2020) 'IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection', Virus Research, 289(198171), pp. 1–7.

Giamarellos-Bourboulis, EJ et al. (2020) 'Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure', Cell Host and Microbe. Elsevier Inc., 27(6), pp. 992–

doi: 10.1016/j.chom.2020.04.009.

Huang, C. et al. (2020) 'Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China', The Lancet, 395(10223), pp. 497–506.

Jayawardena, R. et al. (2020) 'Enhancing immunity in viral infections, with special emphasis on COVID-19: A review', Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Elsevier.

Kloc, M. et al. (2020) 'Development of child immunity in the context of the COVID-

pandemic', Clinical Immunology. Elsevier, 217(June), p. 108510. doi: 10.1016/j.clim.2020.108510.

Li, B. et al. (2020) 'Radiographic and Clinical Features of Children With Coronavirus Disease (COVID-19) Pneumonia', Indian Pediatrics, 57, pp. 423–426.

Nursalam (2020) Writing Literature Review and Systematic Review on Health Education. Surabaya: Faculty of Nursing Universitas Airlangga.

Ozsurekci, Y. et al. (2020) 'Predictive value of cytokine/chemokine responses for the disease severity and management in children and adult cases with COVID- 19', Journal of Medical Virology, 93(5),

pp. 2828–2837. doi:10.1002/jmv.26683.

Peng, D. et al. (2020) 'Risk factors for redetectable positivity in recovered COVID-19 children', Pediatric Pulmonology, 55(12), pp. 3602–3609. doi: 10.1002/ppul.25116.

Rengganis, I. (2018) 'Basic Immunology'. Publishing Agency of the Faculty of Medicine, University of Indonesia.

Rumende, CM, Susanto, EC and Sitorus, TP (2020) 'The Management of Cytokine Storm in COVID-19', Acta medica Indonesiana, 52(3), pp. 306–313.

Sabaka, P. et al. (2021) 'Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak', BMC Infectious Diseases, 21(308), pp . 4–11. doi:10.1186/s12879-021-05945-8.

Shah, J. et al. (2021) 'IgG and IgM antibody formation to spike and nucleocapsid proteins in COVID-19 characterized by multiplex immunoblot assays', BMC Infectious Diseases. BMC Infectious Diseases, 21(325), pp. 1–8.

Shi, Y. et al. (2020) 'COVID-19 infection: the perspectives on immune responses', Cell Death and Differentiation. Springer US, 27(5), pp. 1451–1454. doi:10.1038/s41418-020-0530-3.

Su, L. et al. (2020) 'The different clinical characteristics of corona virus disease cases between children and their families in China–the character of children with COVID-19', Emerging Microbes and Infections, 9(1), pp. 707–713. doi: 10.1080/22221751.2020.1744483.

Sun, D. et al. (2020) 'Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study', World Journal of Pediatrics. Springer Singapore, 16(3), pp. 251–259. doi:10.1007/s12519-020-00354-4.

Tay, MZ et al. (2020) 'The trinity of COVID- 19: immunity, inflammation and intervention', Nature Reviews Immunology, 20(6), pp. 363–374. doi:10.1038/s41577-020-0311-8.

Thevarajan, I. et al. (2020) 'Breadth of concomitant immune responses prior to patient recovery: a case report of non- severe COVID-19', Nature medicine. Nature Publishing Group, 26(4), pp. 453–455

UNICEF (2020) 'COVID-19 and Children in Indonesia Action Agenda to Overcome Socio-Economic Challenges', in Journal of education, psychology and counseling. Jakarta: UNICEF. Available at: www.unicef.org.

Wang, Y. et al. (2020) 'Children Hospitalized With Severe COVID-19 in Wuhan', The Pediatric infectious disease journal. LWW, 39(7), pp. e91--e94.

Xia, W. et al. (2020) 'Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults', Pediatric Pulmonology. John Wiley & Sons, Ltd, 55(5), pp. 1169–1174. doi: 10.1002/ppul.24718.

Xu, Y. et al. (2020) 'Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding', Nature Medicine, 26(4), pp. 502–505. doi:10.1038/s41591-020-0817-4.

Yonker, LM et al. (2020) 'Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses', Journal of Pediatrics, 227, pp. 45-52.e5. doi: 10.1016/j.jpeds.2020.08.037.

Zavareh, MS-H. et al. (2021) 'C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19', Interdisciplinary Perspectives on Infectious Diseases, 15, pp. 1–5. doi: 10.1371/journal.pone.0242400.

Zhang, T. et al. (2020) 'Detectable SARS- CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia', Journal of Medical Virology, 92(7), pp. 909–914. doi:10.1002/jmv.25795.

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Published

03/28/2022

How to Cite

Peristiowati, Y., & Semi, S. (2022). Systematic Review Children’s Immunity Response to Covid-19 Infection. Jurnal Keperawatan, 14(1), 135–156. https://doi.org/10.32583/keperawatan.v14i1.47